antiSMASH: Searching for New Antibiotics Using Open Source Tools

An Antibiotics and Secondary Metabolites Analysis Shell

Kai Blin
Division for Microbiology/Biotechnology

Biological Background

Biotechnology

Biotechnology - Definition

[...] any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use.
The UN Convention on Biological Diversity

Biotechnology

Biofactories

Gene

Nomenclature

Nature's Storage System

DNA

DNA double helix

Amino Acids

Codon Wheel

Central Dogma of Molecular Biology

Gene Cluster

Metabolism

Toxic Waste

Secondary Metabolism

Why do we need more antibiotics?

Non-Ribosomal Peptide Synthesis

Languages Used

Gene Finding

ORF Finding Example

Cluster Identification

Cluster BLAST

Clusters of Orthologous Groups

antiSMASH Web Frontend

Thank you

Pictures used:
pigments.jpg by Dan Brady

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